The concomitant use of DEMEROL Injection with all cytochrome P450 3A4 inhibitors might bring about an increase in meperidine plasma concentrations, which could raise or extend adverse reactions and may bring about most likely fatal respiratory depression.
Animal info Formal reproductive website and developmental toxicology studies for meperidine haven't been concluded.
Overdosage: If you're thinking that you've got taken excessive of this medicine Make contact with a poison Management Heart or unexpected emergency space without delay.
watch sufferers for indications of urinary retention or reduced gastric motility when DEMEROL Injection is utilized concomitantly with anticholinergic prescription drugs.
DEMEROL Injection is a clear, colorless, sterile aqueous Resolution, out there in the subsequent dosage kinds and strengths:
DEMEROL Injection could impair the mental or Bodily capabilities necessary to conduct probably dangerous activities for example driving a vehicle or functioning machinery.
though severe, lifetime-threatening, or lethal respiratory melancholy can arise Anytime all through using DEMEROL Injection, the risk is finest through the initiation of therapy or adhering to a dosage increase.
Parenteral drug abuse is often associated with transmission of infectious diseases such as hepatitis and HIV.
DEMEROL Injection should not be used for an extended length of time Except if the discomfort stays extreme more than enough to have to have an opioid analgesic and for which different therapy solutions continue on to get inadequate.
Meperidine should not be administered intravenously Until a narcotic antagonist plus the services for assisted or controlled respiration are instantly out there. When meperidine is provided parenterally, especially intravenously, the patient really should be lying down.
suggest equally sufferers and caregivers in regards to the challenges of respiratory despair and sedation when DEMEROL Injection is employed with benzodiazepines or other CNS depressants (such as alcohol and illicit medicine). Advise patients to not generate or run heavy equipment until the effects of concomitant use of the benzodiazepine or other CNS depressant have already been decided.
Respiratory despair can manifest Anytime during opioid therapy, In particular when initiating and adhering to dosage boosts with DEMEROL Injection. Consider this risk when deciding on an Preliminary dose and when making dose adjustments [see Warnings and Precautions (five)].
If concomitant use is important, consider dosage reduction of DEMEROL Injection until steady drug effects are accomplished. Monitor people for respiratory despair and sedation at Regular intervals.
Opioid analgesics, such as DEMEROL Injection, can lengthen labor through actions which temporarily decrease the power, duration, and frequency of uterine contractions. nonetheless, this result is just not constant and will be offset by an increased price of cervical dilation, which has a tendency to shorten labor. keep track of neonates subjected to opioid analgesics through labor for signs of excess sedation and respiratory melancholy.